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      Organic synthesis provides opportunities to transform drug discovery

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          Visible light photoredox catalysis with transition metal complexes: applications in organic synthesis.

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            Fluorine in medicinal chemistry.

            It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
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              Organic Photoredox Catalysis.

              In this review, we highlight the use of organic photoredox catalysts in a myriad of synthetic transformations with a range of applications. This overview is arranged by catalyst class where the photophysics and electrochemical characteristics of each is discussed to underscore the differences and advantages to each type of single electron redox agent. We highlight both net reductive and oxidative as well as redox neutral transformations that can be accomplished using purely organic photoredox-active catalysts. An overview of the basic photophysics and electron transfer theory is presented in order to provide a comprehensive guide for employing this class of catalysts in photoredox manifolds.
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                Author and article information

                Journal
                Nature Chemistry
                Nature Chem
                Springer Nature
                1755-4330
                1755-4349
                April 2018
                March 22 2018
                : 10
                : 4
                : 383-394
                Article
                10.1038/s41557-018-0021-z
                29568051
                332b337d-69e3-45d5-a6cb-dbd230f89989
                © 2018

                http://www.springer.com/tdm

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