Reactivity of Small Vessels from Mature to Senescent Female Rabbits

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Abstract

In order to determine if there are differences in reactivity of small arteries of cutaneous and skeletal muscle vascular beds taken from rabbits of different ages, vascular smooth muscle strips were tested in vitro with a variety of drugs. Arteries from the ear and hind limb skeletal muscle were removed from adult female rabbits, aged 6–48 months. Developed force of the vessel strips was measured during exposure to cumulative concentrations of norepinephrine, norepinephrine following propranolol, angiotensin II (skeletal muscle artery only) and histamine (ear artery only). Comparable segments of arteries from rabbits of different ages showed no significant differences in size or in maximum developed force attributable to age. A lack of beta-adrenoceptor activity was indicated in the ear arteries of all adult age groups studied, while propranolol enhanced contractile responses to norepinephrine in skeletal muscle arteries independent of age. Likewise, there were no consistent, age-related changes in the reactivity of either vessel type to norepinephrine, histamine, or angiotensin. This study indicates that small cutaneous and skeletal muscle arteries from mature female rabbits do not undergo any appreciable change in adrenergic and nonadrenergic sensitivity with age.

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Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1985

Publication date (Print): 1985

Publication date (Electronic): 23 September 2008

Volume: 22

Issue: 4

Pages: 172-178

Affiliations

Department of Biological Sciences, Northern Arizona University, Flagstaff, Ariz., USA

Article

Publisher ID: 158599 Other ID: Blood Vessels 1985;22:172–178

DOI: 10.1159/000158599

SO-VID: 334e0b08-60a3-435a-a5a5-9d73f5225619

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 16 August 1984

Date accepted : 06 February 1985

Page count

Pages: 7

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