RKIP and 14-3-3ε exert an opposite effect on human gastric cancer cells SGC7901 by regulating the ERK/MAPK pathway differently.

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Abstract

Raf-1 kinase inhibitor protein (RKIP) inhibits Raf (a key element in the ERK/MAPK pathway) and is regarded as anti-tumoral. In contrast, 14-3-3 is considered protumoral. However, the pathogenetic role of RKIP and 14-3-3ε in gastric cancer is unclear.

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Journal

Journal ID (iso-abbrev): Dig. Dis. Sci.

Title: Digestive diseases and sciences

Publisher: Springer Nature America, Inc

ISSN (Electronic): 1573-2568

ISSN (Print): 0163-2116

Publication date (Electronic): Feb 2013

Volume: 58

Issue: 2

Affiliations

[1 ] Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha City, 410008, Hunan Province, People's Republic of China.

Article

DOI: 10.1007/s10620-012-2341-y

PubMed ID: 22899242

SO-VID: 33702208-e751-45b3-8d61-e260fe4256ae

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