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      Network pharmacology-based identification of key pharmacological pathways of Yin–Huang–Qing–Fei capsule acting on chronic bronchitis

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          Abstract

          For decades in China, the Yin–Huang–Qing–Fei capsule (YHQFC) has been widely used in the treatment of chronic bronchitis, with good curative effects. Owing to the complexity of traditional Chinese herbal formulas, the pharmacological mechanism of YHQFC remains unclear. To address this problem, a network pharmacology-based strategy was proposed in this study. At first, the putative target profile of YHQFC was predicted using MedChem Studio, based on structural and functional similarities of all available YHQFC components to the known drugs obtained from the DrugBank database. Then, an interaction network was constructed using links between putative YHQFC targets and known therapeutic targets of chronic bronchitis. Following the calculation of four topological features (degree, betweenness, closeness, and coreness) of each node in the network, 475 major putative targets of YHQFC and their topological importance were identified. In addition, a pathway enrichment analysis based on the Kyoto Encyclopedia of Genes and Genomes pathway database indicated that the major putative targets of YHQFC are significantly associated with various pathways involved in anti-inflammation processes, immune responses, and pathological changes caused by asthma. More interestingly, eight major putative targets of YHQFC (interleukin [IL]-3, IL-4, IL-5, IL-10, IL-13, FCER1G, CCL11, and EPX) were demonstrated to be associated with the inflammatory process that occurs during the progression of asthma. Finally, a molecular docking simulation was performed and the results exhibited that 17 pairs of chemical components and candidate YHQFC targets involved in asthma pathway had strong binding efficiencies. In conclusion, this network pharmacology-based investigation revealed that YHQFC may attenuate the inflammatory reaction of chronic bronchitis by regulating its candidate targets, which may be implicated in the major pathological processes of the asthma pathway.

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          Most cited references 63

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                Author and article information

                Journal
                Int J Chron Obstruct Pulmon Dis
                Int J Chron Obstruct Pulmon Dis
                International Journal of COPD
                International Journal of Chronic Obstructive Pulmonary Disease
                Dove Medical Press
                1176-9106
                1178-2005
                2017
                22 December 2016
                : 12
                : 85-94
                Affiliations
                [1 ]School of Chinese Materia Medica, Beijing University of Chinese Medicine
                [2 ]Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing
                [3 ]The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha
                [4 ]School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin
                [5 ]School of Basic Medicine, Shandong University of Chinese Medicine, Jinan, China
                Author notes
                Correspondence: Haiyu Xu; Hongjun Yang, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Number 16 Nanxiaojie, Dongzhimennei, Beijing 100700, China, Tel +86 137 0100 4691; +86 139 1000 0292, Fax +86 6401 4411 2948, Email hy_xu627@ 123456163.com ; hongjun0420@ 123456vip.sina.com
                [*]

                These authors contributed equally to this work

                Article
                copd-12-085
                10.2147/COPD.S121079
                5191847
                © 2017 Yu et al. This work is published and licensed by Dove Medical Press Limited

                The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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