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      Ultrasound-Mediated EGF-Coated-Microbubble Cavitation in Dressings for Wound-Healing Applications

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          Abstract

          The feasibility of ultrasound (US) controlled cavitation for transdermal drug delivery (TDD) using gas-filled microbubbles (MBs) has been explored. However, liquid or gel-type MBs is not easy used for TDD. The present study investigated a new treatment model for evaluating the US-mediated liquid-type epidermal growth factor (EGF)-coated lysozyme microbubble (LYMB) cavitation in a wound dressing for enhancing wound healing. The maximum loading efficacy of EGF onto LYMBs was 19.40 ± 0.04%. In terms of the in vitro treatment efficacy, the growth of Staphylococcus aureus was inhibited by 97.50 ± 1.50% in the group with LYMBs exposed to 3 W/cm 2 US. During 21 days in vivo wound healing experiments, the recovery rate during the first 6 days was significant higher in the group with EGF-LYMB dressings and US exposure (day 6: 54.28 ± 3.26%) than in the control group (day 6: 26.36 ± 3.34%) ( p < 0.05). Our results show that the new model can significantly reduce the treatment duration during wound healing.

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          The Wound Healing Process: An Overview of the Cellular and Molecular Mechanisms

          T. Velnar, T. Bailey, V Smrkolj (2009)
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            Survey over image thresholding techniques and quantitative performance evaluation

            Bu¨lent Sankur (2004)
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              Influence of pH on wound-healing: a new perspective for wound-therapy?

              Lars Alexander Schneider, Andreas Korber, Stephan Grabbe … (2007)
              Wound healing is a complex regeneration process, which is characterised by intercalating degradation and re-assembly of connective tissue and epidermal layer. The pH value within the wound-milieu influences indirectly and directly all biochemical reactions taking place in this process of healing. Interestingly it is so far a neglected parameter for the overall outcome. For more than three decades the common assumption amongst physicians was that a low pH value, such as it is found on normal skin, is favourable for wound healing. However, investigations have shown that in fact some healing processes such as the take-rate of skin-grafts require an alkaline milieu. The matter is thus much more complicated than it was assumed. This review article summarises the existing literature dealing with the topic of pH value within the wound-milieu, its influence on wound healing and critically discusses the currently existing data in this field. The conclusion to be drawn at present is that the wound pH indeed proves to be a potent influential factor for the healing process and that different pH ranges are required for certain distinct phases of wound healing. Further systematic data needs to be collected for a better understanding of the pH requirements under specific circumstances. This is important as it will help to develop new pH targeted therapeutic strategies.
              Article 0 comments Cited 245 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Ai-Ho Liao: aiho@mail.ntust.edu.tw
                Journal
                Journal ID (nlm-ta): Sci Rep
                Journal ID (iso-abbrev): Sci Rep
                Title: Scientific Reports
                Publisher: Nature Publishing Group UK (London )
                ISSN (Electronic): 2045-2322
                Publication date (Electronic): 29 May 2018
                Publication date PMC-release: 29 May 2018
                Publication date Collection: 2018
                Volume: 8
                Electronic Location Identifier: 8327
                Affiliations
                [1 ]ISNI 0000 0000 9744 5137, GRID grid.45907.3f, Graduate Institute of Biomedical Engineering, , National Taiwan University of Science and Technology, ; Taipei, 10607 Taiwan
                [2 ]ISNI 0000 0004 0634 0356, GRID grid.260565.2, Department of Biomedical Engineering, , National Defense Medical Center, ; Taipei, 11490 Taiwan
                [3 ]ISNI 0000 0004 0634 0356, GRID grid.260565.2, Graduate Institute of Medical Sciences, , National Defense Medical Center, ; Taipei, 11490 Taiwan
                [4 ]Department of Dermatology, Tri-Service General Hospital, National Defense Medical Center, Taipei, 11490 Taiwan
                [5 ]ISNI 0000 0004 0634 0356, GRID grid.260565.2, Department of Biochemistry, , National Defense Medical Center, ; Taipei, 11490 Taiwan
                [6 ]Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, 11490 Taiwan
                Article
                Publisher ID: 26702
                DOI: 10.1038/s41598-018-26702-z
                PMC ID: 5974178
                PubMed ID: 29844469
                SO-VID: 33a69ba2-a644-49d1-8663-6c46896b9b4f
                Copyright © © The Author(s) 2018
                License:

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                Date received : 16 January 2018
                Date accepted : 17 May 2018
                Categories
                Subject: Article
                Custom metadata
                issue-copyright-statement © The Author(s) 2018

                ScienceOpen disciplines: Uncategorized
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