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      Retracted: Paeoniflorin Attenuated TREM-1-Mediated Inflammation in THP-1 Cells

      retraction
      Journal of Healthcare Engineering
      Hindawi

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          Abstract

          This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation The presence of these indicators undermines our confidence in the integrity of the article's content and we cannot, therefore, vouch for its reliability. Please note that this notice is intended solely to alert readers that the content of this article is unreliable. We have not investigated whether authors were aware of or involved in the systematic manipulation of the publication process. Wiley and Hindawi regrets that the usual quality checks did not identify these issues before publication and have since put additional measures in place to safeguard research integrity. We wish to credit our own Research Integrity and Research Publishing teams and anonymous and named external researchers and research integrity experts for contributing to this investigation. The corresponding author, as the representative of all authors, has been given the opportunity to register their agreement or disagreement to this retraction. We have kept a record of any response received.

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          Paeoniflorin Attenuated TREM-1-Mediated Inflammation in THP-1 Cells

          Sepsis is caused by bacterial infections or viral infections. Clinically, there exist confirmed or highly suspected infection foci. Mortality caused by septic shock remains in a high rate even though antibiotic treatment works effectively. In this study, we treat THP-1 cells with 1 ug/mL LPS (lipopolysaccharide) and add paeoniflorin or LR-12 inhibitor. TREM-1 (triggering receptor expressed on myeloid cells-1), IL-6, IL-1 β , and TNF- α (tumour necrosis factor alpha (a)-cachectin) were detected by ELISA and qRT-PCR, and western blotting is performed to detect related proteins in the NF- κ B signaling pathway. As a result, paeoniflorin can significantly reduce the production of LPS-stimulated TREM-1 as well as inflammatory factors and attenuate the phosphorylation of NF- κ B signaling pathway-related factors, such as p65 and I κ B α . At the same time, the combined effect of paeoniflorin and LR-12 is more significant. The results of this study solidly prove that paeoniflorin plays a role in inhibiting TREM-1-mediated inflammation and the NF- κ B pathway could be a potential mechanism of action.
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            Author and article information

            Contributors
            Journal
            J Healthc Eng
            J Healthc Eng
            JHE
            Journal of Healthcare Engineering
            Hindawi
            2040-2295
            2040-2309
            2023
            20 September 2023
            20 September 2023
            : 2023
            : 9791859
            Affiliations
            Article
            10.1155/2023/9791859
            10533235
            37772027
            33a95438-34ca-4535-bbf0-f5be3db55e9d
            Copyright © 2023 Journal of Healthcare Engineering.

            This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

            History
            : 19 September 2023
            : 19 September 2023
            Categories
            Retraction

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