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      Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes.

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          Abstract

          Membrane currents of ventricular cardiomyocytes isolated from control, diabetic and insulin-treated diabetic Wistar rats have been measured using the whole cell configuration of the patch-clamp technique. Insulin restored the density of the 4-aminopyridine-sensitive early transient component of the calcium-independent outward potassium currents which decreased in diabetes. The inactivation rate of the transients increased in diabetes and was normalised by insulin. The late 4-aminopyridine-insensitive component of the outward currents showed the same diabetes- and insulin-related changes. This current could reflect the activation of the delayed rectifier channels although pharmacological identification of this component could not be achieved.

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          Author and article information

          Journal
          Gen. Physiol. Biophys.
          General physiology and biophysics
          0231-5882
          0231-5882
          Jun 1995
          : 14
          : 3
          Affiliations
          [1 ] Department of Physiology, University Medical School of Debrecen, Hungary.
          Article
          8586253
          33b1d2f4-1252-4a0b-b81c-3deb16000858
          History

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