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      Ritonavir: an extraordinary example of conformational polymorphism.

      Pharmaceutical Research
      Springer Science and Business Media LLC

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          Abstract

          In the summer of 1998, Norvir semi-solid capsules supplies were threatened as a result of a new much less soluble crystal form of ritonavir. This report provides characterization of the two polymorphs and the structures and hydrogen bonding network for each form.

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          Journal
          11474792
          10.1023/a:1011052932607

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