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      Effects of losartan on whole body, skeletal muscle and vascular insulin responses in obesity/insulin resistance without hypertension.

      1 , , , ,
      Diabetes, obesity & metabolism
      Wiley

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          Abstract

          Renin-angiotensin system antagonists have been found to improve glucose metabolism in obese hypertensive and type 2 diabetic subjects. The mechanism of these effects is not well understood. We hypothesized that the angiotensin receptor antagonist losartan would improve insulin-mediated vasodilation, and thereby improve insulin-stimulated glucose uptake in skeletal muscle of insulin-resistant subjects.

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          Author and article information

          Journal
          Diabetes Obes Metab
          Diabetes, obesity & metabolism
          Wiley
          1463-1326
          1462-8902
          Mar 2012
          : 14
          : 3
          Affiliations
          [1 ] Department of Medicine, Division of Endocrinology & Metabolism, Indiana University School of Medicine, 541 North Clinical Drive, Indianapolis, IN, USA.
          Article
          NIHMS336849
          10.1111/j.1463-1326.2011.01522.x
          3277658
          22051059
          33d688b5-97f3-4587-aea7-d899b399684f
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