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      Rapamycin reduces renal hypoxia, interstitial inflammation and fibrosis in a rat model of unilateral ureteral obstruction.

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          Abstract

          The purpose of this study was to explore effects of rapamycin on renal hypoxia, interstitial inflammation and fibrosis, and the expression of transforming growth factor β1 (TGF-β1), vascular endothelial growth factor (VEGF), Flk-1 and Flt-1 in a rat model of unilateral ureteral obstruction (UUO).

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          Author and article information

          Journal
          Clin Invest Med
          Clinical and investigative medicine. Medecine clinique et experimentale
          1488-2353
          0147-958X
          Jun 01 2014
          : 37
          : 3
          Affiliations
          [1 ] . ding.xiaoqiang@zs-hospital.sh.cn.
          Article
          10.25011/cim.v37i3.21381
          24895989
          33db5ad8-f0e4-4256-b575-d6189d59642f
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