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      A Meta-Analysis of the Efficacy of L-Carnitine/L-Acetyl-Carnitine or N-Acetyl-Cysteine in Men With Idiopathic Asthenozoospermia

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          Abstract

          The meta-analysis was performed to access efficacy of L-carnitine/L-acetyl-carnitine (LC/LAC) and N-acetyl-cysteine (NAC) in men with idiopathic asthenozoospermia. We researched PubMed, EMBASE, and Cochrane Library databases and references to related articles. Finally, seven articles including 621 patients were analyzed. The results indicated that LC/LAC and NAC had a considerable improvement in sperm motility ( p = .03 and p < .0001, respectively) and normal morphology ( p = .006, p = .0002, respectively) compared with the placebo group. Besides, NAC had a significantly greater increase in sperm concentration ( p < .00001) and ejaculate volume ( p = .002) compared with the placebo group, and there was no significant difference in LC/LAC. For the analysis of serum hormones, NAC had no obvious differences in improving the serum testosterone, luteinizing hormone, follicle-stimulating hormone, and prolactin compared with non-treatment group. Conclusively, LC/LAC and NAC showed a greater improvement in sperm motility and normal morphology. Moreover, NAC has a positive effect on sperm concentration and ejaculate volume, whereas no obvious effect was observed in serum hormones.

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          Most cited references 36

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          Meta-analysis in clinical trials

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            Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

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                Author and article information

                Journal
                Am J Mens Health
                Am J Mens Health
                JMH
                spjmh
                American Journal of Men's Health
                SAGE Publications (Sage CA: Los Angeles, CA )
                1557-9883
                1557-9891
                27 April 2021
                Mar-Apr 2021
                : 15
                : 2
                Affiliations
                [1 ]Department of Urology, Beijing TianTan Hospital, Capital Medical University, Fengtai District, Beijing, China
                [2 ]Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China
                Author notes
                Yong Zhang MD, Department of Urology, Beijing TianTan Hospital, Capital Medical University. No.119 South 4th Ring West Road, Fengtai District, Beijing 100070, China. Email: 1310264997@ 123456qq.com
                [*]

                Guangzhu Wei and Zhongbao Zhou contributed equally to this work as co-first authors.

                Article
                10.1177_15579883211011371
                10.1177/15579883211011371
                8108089
                33906513
                © The Author(s) 2021

                This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

                Funding
                Funded by: Beijing Municipal Administration of Hospitals’ Ascent Plan, ;
                Award ID: DFL20190502
                Funded by: Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support, ;
                Award ID: ZYLX201820
                Funded by: National Nature Science Foundation of China, ;
                Award ID: 81801429
                Categories
                Male Sexual and Reproductive Health
                Original Article
                Custom metadata
                March-April 2021
                ts1

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