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      Tubulointerstitial Changes as a Major Determinant in the Progression of Renal Damage

      American Journal of Kidney Diseases
      Elsevier BV

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          Abstract

          Tubulointerstitial injury is an invariant finding in the chronically diseased kidney, irrespective of the type of disease or the compartment in which the disease originates. Such histologic changes are functionally significant in that scores for such damage, rather than glomerular injury, correlate with decline of renal function. This review summarizes (1) clinical evidence attesting to tubulointerstitial changes as an index of functional impairment, (2) mechanisms by which tubulointerstitial injury impairs renal function, and (3) interactions of pathologic processes in the vascular, glomerular, tubular, and interstitial compartments that culminate in tubulointerstitial injury. This report concludes with a review of interstitial fibrosis, a pathologic process regarded as an irreversible outcome from tubulointerstitial injury.

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          Author and article information

          Journal
          American Journal of Kidney Diseases
          American Journal of Kidney Diseases
          Elsevier BV
          02726386
          July 1992
          July 1992
          : 20
          : 1
          : 1-17
          Article
          10.1016/S0272-6386(12)80312-X
          1621674
          340989b6-4345-4037-932e-84fd66fbb840
          © 1992

          https://www.elsevier.com/tdm/userlicense/1.0/

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