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      Triggering signaling cascades by receptor tyrosine kinases

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      Trends in Biochemical Sciences
      Elsevier BV

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          Abstract

          Growth factor receptors that are tyrosine kinases (RTKs) regulate growth and differentiation of cells in many organisms, including flies, worms, frogs, mice and humans. There has been recent progress in understanding the mechanism by which these receptors transduce signals. Worm and insect studies on RTKs have relied primarily on genetics, while the mammalian studies have employed a combination of molecular genetics and biochemistry. While many RTKs seem to have unique features, there are also many general signal transduction principles that emerge from these studies. In this review, we will focus on common signaling molecules, using RTKs from both vertebrates and invertebrates as examples.

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          Author and article information

          Journal
          Trends in Biochemical Sciences
          Trends in Biochemical Sciences
          Elsevier BV
          09680004
          October 1992
          October 1992
          : 17
          : 10
          : 374-378
          Article
          10.1016/0968-0004(92)90003-R
          1455504
          341c7e2d-2b85-4550-a76c-cd33051aa8de
          © 1992

          https://www.elsevier.com/tdm/userlicense/1.0/

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