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      Stems Cells and the Pathways to Aging and Cancer

      , ,
      Cell
      Elsevier BV

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          Abstract

          The aging of tissue-specific stem cell and progenitor cell compartments is believed to be central to the decline of tissue and organ integrity and function in the elderly. Here, we examine evidence linking stem cell dysfunction to the pathophysiological conditions accompanying aging, focusing on the mechanisms underlying stem cell decline and their contribution to disease pathogenesis.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          February 2008
          February 2008
          : 132
          : 4
          : 681-696
          Article
          10.1016/j.cell.2008.01.036
          18295583
          3431daf8-1dba-427d-b7ba-95f57b0fe6fa
          © 2008

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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