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      Protein biomarkers for male artificial insemination subfertility in bovine spermatozoa

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          Abstract

          Background

          Although artificial insemination ( AI) technique is an established biotechnology for bovine reproduction, the results of AI (conception rates) have a tendency to decline gradually. To our annoyance, moreover, AI‐subfertile bulls have been occasionally found in the AI centers. To resolve these serious problems, it is necessary to control the sperm quality more strictly by the examinations of sperm molecules.

          Methods

          We reviewed a number of recent articles regarding potentials of bovine sperm proteins as the biomarkers for bull AI‐subfertility and also showed our unpublished supplemental data on the bull AI‐subfertility associated proteins.

          Main findings

          Bull AI‐subfertility is caused by the deficiency or dysfunctions of various molecules including regulatory proteins of ATP synthesis, acrosomal proteins, nuclear proteins, capacitation‐related proteins and seminal plasma proteins.

          Conclusion

          In order to control the bovine sperm quality more strictly by the molecular examinations, it is necessary to select suitable sperm protein biomarkers for the male reproductive problems which happen in the AI centers.

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          Most cited references103

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          Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells.

          Katsuhiko Hayashi, Hiroshi Ohta, Kazuki Kurimoto … (2011)
          The generation of properly functioning gametes in vitro requires reconstitution of the multistepped pathway of germ cell development. We demonstrate here the generation of primordial germ cell-like cells (PGCLCs) in mice with robust capacity for spermatogenesis. PGCLCs were generated from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) through epiblast-like cells (EpiLCs), a cellular state highly similar to pregastrulating epiblasts but distinct from epiblast stem cells (EpiSCs). Reflecting epiblast development, EpiLC induction from ESCs/iPSCs is a progressive process, and EpiLCs highly competent for the PGC fate are a transient entity. The global transcription profiles, epigenetic reprogramming, and cellular dynamics during PGCLC induction from EpiLCs meticulously capture those associated with PGC specification from the epiblasts. Furthermore, we identify Integrin-β3 and SSEA1 as markers that allow the isolation of PGCLCs with spermatogenic capacity from tumorigenic undifferentiated cells. Our findings provide a paradigm for the first step of in vitro gametogenesis. Copyright © 2011 Elsevier Inc. All rights reserved.
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            The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs.

            Naokazu Inoue, Masahito Ikawa, Ayako Isotani … (2005)
            Representing the 60 trillion cells that build a human body, a sperm and an egg meet, recognize each other, and fuse to form a new generation of life. The factors involved in this important membrane fusion event, fertilization, have been sought for a long time. Recently, CD9 on the egg membrane was found to be essential for fusion, but sperm-related fusion factors remain unknown. Here, by using a fusion-inhibiting monoclonal antibody and gene cloning, we identify a mouse sperm fusion-related antigen and show that the antigen is a novel immunoglobulin superfamily protein. We have termed the gene Izumo and produced a gene-disrupted mouse line. Izumo-/- mice were healthy but males were sterile. They produced normal-looking sperm that bound to and penetrated the zona pellucida but were incapable of fusing with eggs. Human sperm also contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamster eggs.
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              Fertilizing capacity of spermatozoa deposited into the fallopian tubes.

              Chawnshang Chang (1951)
              Article 0 comments Cited 191 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Hiroshi Harayama: harayama@kobe-u.ac.jp
                Journal
                Journal ID (nlm-ta): Reprod Med Biol
                Journal ID (iso-abbrev): Reprod. Med. Biol
                Journal ID (doi): 10.1111/(ISSN)1447-0578
                Journal ID (publisher-id): RMB2
                Title: Reproductive Medicine and Biology
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Print): 1445-5781
                ISSN (Electronic): 1447-0578
                Publication date (Electronic): 20 March 2017
                Publication date Collection: April 2017
                Volume: 16
                Issue: 2 ( doiID: 10.1111/rmb2.2017.16.issue-2 )
                Pages: 89-98
                Affiliations
                [ 1 ] Division of Animal Science Department of Bioresource Science Graduate School of Agricultural Science Kobe University Kobe Japan
                [ 2 ] Department of Obstetrics and Gynecology Shiga University of Medical Science Otsu Japan
                [ 3 ] Research Institute for Microbial Diseases Osaka University Suita Osaka Japan
                Author notes
                [*] [* ] Correspondence

                Hiroshi Harayama, Laboratory of Reproductive Biology, Division of Animal Science, Department of Bioresource Science, Graduate School of Agricultural Science, Kobe University, Kobe, Japan.

                Email: harayama@ 123456kobe-u.ac.jp

                Article
                Publisher ID: RMB212021
                DOI: 10.1002/rmb2.12021
                PMC ID: 5661804
                SO-VID: 344230b0-9077-4d3a-9d04-2d14f8997244
                Copyright © © 2017 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.
                License:

                This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 08 December 2016
                Date accepted : 03 January 2017
                Page count
                Figures: 3, Tables: 0, Pages: 10, Words: 8059
                Categories
                Subject: Review Article
                Subject: Review Articles
                Custom metadata
                source-schema-version-number 2.0
                component-id rmb212021
                cover-date April 2017
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_NLMPMC version:5.2.7 mode:remove_FC converted:04.12.2017

                Keywords: acrosome,artificial insemination,cattle,sperm,subfertility
                Data availability:
                Keywords: acrosome, artificial insemination, cattle, sperm, subfertility

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