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      Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway

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          Abstract

          Objective

          This study was to detect the protective effects of Houttuynia cordata extract on the damage induced by propofol in hippocampal neuron of rats.

          Methods

          Propofol-induced neuron injury model and H. cordata extract administration were conducted. Immunofluorescence and immunoblot were conducted for the effect of H. cordata extract on neuronal activity and inflammation were detected in this model.

          Results

          H. cordata extracts increased neuronal activity, and reduced propofol-induced neuronal inflammation levels. H. cordata extract also reduced propofol-induced neuronal apoptosis. Mechanically, we noticed H. cordata extract activated phosphoinositide 3-kinase/AKT pathway and suppressed Toll-like receptor 4/nuclear factor kappaB pathway, therefore protected propofol-induced injury of rat hippocampal neurons.

          Conclusion

          Our findings provide references for anesthetic use in infants and young children.

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          Flavonoids from Houttuynia cordata attenuate H1N1-induced acute lung injury in mice via inhibition of influenza virus and Toll-like receptor signalling

          Li-jun Ling, Yan Lu, Yun-yi Zhang … (2020)
          Influenza virus is one of the most important human pathogens, causing substantial seasonal and pandemic morbidity and mortality. Houttuynia cordata is a traditionally used medicinal plant for the treatment of pneumonia. Flavonoids are one of the major bioactive constituents of Houttuynia cordata.
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            Houttuynia cordata polysaccharides ameliorate pneumonia severity and intestinal injury in mice with influenza virus infection

            Xunlong Shi, Hong Li, Lijun Ling … (2018)
            Article 0 comments Cited 38 times – based on 0 reviews     Review now
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              Combined signaling through ERK, PI3K/AKT, and RAC1/p38 is required for met-triggered cortical neuron migration.

              Flavio Maina, Thijs Drenth, Fabienne Lamballe … (2006)
              Cell migration is a complex biological process playing a key role in physiological and pathological conditions. During central nervous system development, positioning and function of cortical neurons is tightly regulated by cell migration. Recently, signaling events involving the urokinase-type plasminogen activator receptor, which is a key regulator for the activation of hepatocyte growth factor (HGF), have been implicated in modulating cortical neuron migration. However, the intracellular pathways controlling neuronal migration triggered by the HGF receptor Met have not been elucidated. By combining pharmacological and genetic approaches, we show here that the Ras/ERK pathway and phosphatidylinositol 3-kinase (PI3K) are both required for cortical neuron migration. By dissecting the downstream signals necessary for this event, we found that Rac1/p38 and Akt are required, whereas the c-Jun N-terminal kinase (JNK) and mTOR/p70(s6k) pathways are dispensable. This study demonstrates that concomitant activation of the Ras/ERK, PI3K/Akt, and Rac1/p38 pathways is required to achieve full capacity of cortical neurons to migrate upon HGF stimulation.
              Article 0 comments Cited 31 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Neuroreport
                Journal ID (iso-abbrev): Neuroreport
                Journal ID (publisher-id): NR
                Title: Neuroreport
                Publisher: Lippincott Williams & Wilkins
                ISSN (Print): 0959-4965
                ISSN (Electronic): 1473-558X
                Publication date (Electronic): 11 March 2021
                Publication date (Print): 5 May 2021
                Volume: 32
                Issue: 7
                Pages: 577-582
                Affiliations
                [a ]Department of Anesthesiology, Wuhan Children’s Hospital
                [b ]Department of Anesthesiology, Wuhan JinYinTan Hospital, Wuhan City, Hubei Province
                [c ]Department of Anesthesiology, Bishan Hospital, Chongqing, China
                Author notes
                Correspondence to Liu Yang, MD, Department of Anesthesiology, Bishan Hospital, No. 9 Shuangxing Avenue, Biquan Street, Bishan District, Chongqing City 402760, China, Tel: +86 023 41411672; e-mail: yangliu_1223@ 123456163.com
                Article
                Accession ID: 00001
                DOI: 10.1097/WNR.0000000000001627
                PMC ID: 8048724
                PubMed ID: 33850081
                SO-VID: 3442ec27-06f6-46e7-b883-23699b02a883
                Copyright © Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

                History
                Date received : 25 December 2020
                Date accepted : 29 January 2021
                Categories
                Subject: Degeneration and Repair
                Custom metadata
                OPEN-ACCESS TRUE

                Keywords: houttuynia cordata extract,hippocampal neuron,propofol,pi3k/akt pathway,toll-like receptor 4/nf-κb pathway
                Data availability:
                Keywords: houttuynia cordata extract, hippocampal neuron, propofol, pi3k/akt pathway, toll-like receptor 4/nf-κb pathway

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