+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      A Diurnal Rhythm of Immunoreactive α-Melanocyte-Stimulating Hormone in Discrete Regions of the Rat Brain

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          A significant diurnal variation in α-melanocyte stimulating hormone ( α-MSH) concentrations was observed in discrete regions of the rat brain. During the 12 h light: 12 h dark cycle, α-MSH concentrations in each case were highest during the light period and lowest during the dark period. At 09.00 h, 3 h after lights were turned on, the peak α-MSH concentration occurred in the median eminence, the arcuate and dorsomedial hypothalamic nuclei and the periventricular thalamic nucleus. The paraventricular and anterior hypothalamic nuclei had highest α-MSH concentrations at 13.00 h. In the medial preoptic nucleus, the peak α-MSH concentrations appeared at 17.00 h. These changes in α-MSH content may reflect an α-MSH role in circadian variations in behavioral and neuroendocrine processes.

          Related collections

          Author and article information

          S. Karger AG
          26 March 2008
          : 29
          : 4
          : 281-287
          Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md. And Division of Clinical Pharmacology, Department of Pharmacology and Medicine, Howard University, Washington, D.C.
          122934 Neuroendocrinology 1979;29:281–287
          © 1979 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Original Paper


          Comment on this article