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      A Diurnal Rhythm of Immunoreactive α-Melanocyte-Stimulating Hormone in Discrete Regions of the Rat Brain

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          Abstract

          A significant diurnal variation in α-melanocyte stimulating hormone ( α-MSH) concentrations was observed in discrete regions of the rat brain. During the 12 h light: 12 h dark cycle, α-MSH concentrations in each case were highest during the light period and lowest during the dark period. At 09.00 h, 3 h after lights were turned on, the peak α-MSH concentration occurred in the median eminence, the arcuate and dorsomedial hypothalamic nuclei and the periventricular thalamic nucleus. The paraventricular and anterior hypothalamic nuclei had highest α-MSH concentrations at 13.00 h. In the medial preoptic nucleus, the peak α-MSH concentrations appeared at 17.00 h. These changes in α-MSH content may reflect an α-MSH role in circadian variations in behavioral and neuroendocrine processes.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1979
          1979
          26 March 2008
          : 29
          : 4
          : 281-287
          Affiliations
          Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Md. And Division of Clinical Pharmacology, Department of Pharmacology and Medicine, Howard University, Washington, D.C.
          Article
          122934 Neuroendocrinology 1979;29:281–287
          10.1159/000122934
          574621
          © 1979 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Original Paper

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