Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

Introduction to ISBGMO12: biosafety research past, present and future

, ,

Transgenic Research

Springer International Publishing

Read this article at

ScienceOpenPublisherPMC
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Related collections

      Most cited references 23

      • Record: found
      • Abstract: found
      • Article: not found

      Assessment of risk of insect-resistant transgenic crops to nontarget arthropods.

      An international initiative is developing a scientifically rigorous approach to evaluate the potential risks to nontarget arthropods (NTAs) posed by insect-resistant, genetically modified (IRGM) crops. It adapts the tiered approach to risk assessment that is used internationally within regulatory toxicology and environmental sciences. The approach focuses on the formulation and testing of clearly stated risk hypotheses, making maximum use of available data and using formal decision guidelines to progress between testing stages (or tiers). It is intended to provide guidance to regulatory agencies that are currently developing their own NTA risk assessment guidelines for IRGM crops and to help harmonize regulatory requirements between different countries and different regions of the world.
        Bookmark
        • Record: found
        • Abstract: found
        • Article: not found

        Recommendations for the design of laboratory studies on non-target arthropods for risk assessment of genetically engineered plants

        This paper provides recommendations on experimental design for early-tier laboratory studies used in risk assessments to evaluate potential adverse impacts of arthropod-resistant genetically engineered (GE) plants on non-target arthropods (NTAs). While we rely heavily on the currently used proteins from Bacillus thuringiensis (Bt) in this discussion, the concepts apply to other arthropod-active proteins. A risk may exist if the newly acquired trait of the GE plant has adverse effects on NTAs when they are exposed to the arthropod-active protein. Typically, the risk assessment follows a tiered approach that starts with laboratory studies under worst-case exposure conditions; such studies have a high ability to detect adverse effects on non-target species. Clear guidance on how such data are produced in laboratory studies assists the product developers and risk assessors. The studies should be reproducible and test clearly defined risk hypotheses. These properties contribute to the robustness of, and confidence in, environmental risk assessments for GE plants. Data from NTA studies, collected during the analysis phase of an environmental risk assessment, are critical to the outcome of the assessment and ultimately the decision taken by regulatory authorities on the release of a GE plant. Confidence in the results of early-tier laboratory studies is a precondition for the acceptance of data across regulatory jurisdictions and should encourage agencies to share useful information and thus avoid redundant testing.
          Bookmark
          • Record: found
          • Abstract: not found
          • Article: not found

          Evaluation of genetically engineered crops using transcriptomic, proteomic, and metabolomic profiling techniques.

            Bookmark

            Author and article information

            Affiliations
            [ ]Syngenta, Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY UK
            [ ]Donald Danforth Plant Science Center, St. Louis, MO 63132 USA
            [ ]Agroscope, Institute for Sustainability Sciences ISS, Reckenholzstr. 191, 8104 Zurich, Switzerland
            Contributors
            alan.raybould@syngenta.com
            Journal
            Transgenic Res
            Transgenic Res
            Transgenic Research
            Springer International Publishing (Cham )
            0962-8819
            1573-9368
            14 May 2014
            14 May 2014
            2014
            : 23
            : 6
            : 911-914
            24823764
            4204009
            9794
            10.1007/s11248-014-9794-z
            © The Author(s) 2014

            Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

            Categories
            Isbgmo12
            Custom metadata
            © Springer International Publishing Switzerland 2014

            Genetics

            Comments

            Comment on this article