Homoisoflavonoids and xanthones from the tubers of wild and in vitro regenerated Ledebouria graminifolia and cytotoxic activities of some of the homoisoflavonoids
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Abstract
Eleven homoisoflavonoids and two xanthones were isolated and characterized from the
bulbs of Ledebouria graminifolia. Five of the homoisoflavonoids are new compounds
and were identified as: 5-hydroxy-7-methoxy-3-(4'-hydroxybenzyl)-4-chromanone, 5-hydroxy-6,7-dimethoxy-3-(4'-hydroxybenzyl)-4-chromanone,
5,7,8-trimethoxy-3-(4'-hydroxybenzyl)-4-chromanone, 5-hydroxy-3',4',7-trimethoxyspiro[2H-1-benzopyran-7'-bicyclo[4.2.0]octa-trien]-4-one,
5,7-dihydroxy-3',4'-dimethoxyspiro[2H-1-benzopyran-7'-bicyclo[4.2.0]octa-trien]-4-one.
Structures were elucidated by extensive 1D, and 2D NMR spectroscopy and HRMS. A method
for tissue culture was developed and the bulbs of mature plants were found to contain
all the compounds isolated from the wild specimens of L. graminifolia.