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      Vasopressin Concentrations in Hypophysial Portal Plasma: Insignificant Reduction following Removal of the Posterior Pituitary Gland

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          Abstract

          This study was designed to determine the relative contribution of vasopressin-secreting nerve terminals in the median eminence compared to those in posterior pituitary to the high concentrations of the hormone in hypophysial portal blood. Vasopressin was measured by radioimmunoassay in plasma obtained by microcannulation of individual long portal veins of 8 intact male Long-Evans rats (2.0 ± 0.44 ng/ml SEM), and in 8 in which the posterior pituitary was removed just prior to collection (1.5 ± 0.3 ng/ml SEM). Since there was no significant difference (p = 0.23, NS) in the concentration of vasopressin in portal plasma after removal of the posterior pituitary gland, these results suggest that the direct vasopressin pathway to the median eminence is the major source of vasopressin in portal blood of the rat.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1981
          1981
          26 March 2008
          : 33
          : 2
          : 88-90
          Affiliations
          Departments of Neurology, Pharmacology a, and Anatomy b, College of Physicians and Surgeons, Columbia University, New York, N.Y., USA
          Article
          123208 Neuroendocrinology 1981;33:88–90
          10.1159/000123208
          7266774
          © 1981 S. Karger AG, Basel

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          Page count
          Pages: 3
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          Original Paper

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