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      Amino acid signalling upstream of mTOR.

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          Abstract

          Mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that is part of mTOR complex 1 (mTORC1), a master regulator that couples amino acid availability to cell growth and autophagy. Multiple cues modulate mTORC1 activity, such as growth factors, stress, energy status and amino acids. Although amino acids are key environmental stimuli, exactly how they are sensed and how they activate mTORC1 is not fully understood. Recently, a model has emerged whereby mTORC1 activation occurs at the lysosome and is mediated through an amino acid sensing cascade involving RAG GTPases, Ragulator and vacuolar H(+)-ATPase (v-ATPase).

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0080
          1471-0072
          Mar 2013
          : 14
          : 3
          Affiliations
          [1 ] Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA.
          Article
          nrm3522 NIHMS568642
          10.1038/nrm3522
          3988467
          23361334
          34ab915d-767b-456f-a06e-ce56462d4be4
          History

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