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      Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing.

      1 ,
      EMBO reports
      Springer Science and Business Media LLC

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          Abstract

          Accumulating evidence indicates that there is extensive crosstalk between integrins and TGF-beta signalling. TGF-beta affects integrin-mediated cell adhesion and migration by regulating the expression of integrins, their ligands and integrin-associated proteins. Conversely, several integrins directly control TGF-beta activation. In addition, a number of integrins can interfere with both Smad-dependent and Smad-independent TGF-beta signalling in different ways, including the regulation of the expression of TGF-beta signalling pathway components, the physical association of integrins with TGF-beta receptors and the modulation of downstream effectors. Reciprocal TGF-beta-integrin signalling is implicated in normal physiology, as well as in a variety of pathological processes including systemic sclerosis, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease and cancer; thus, integrins could provide attractive therapeutic targets to interfere with TGF-beta signalling in these processes.

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          Author and article information

          Journal
          EMBO Rep
          EMBO reports
          Springer Science and Business Media LLC
          1469-3178
          1469-221X
          Feb 2010
          : 11
          : 2
          Affiliations
          [1 ] Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
          Article
          embor2009276
          10.1038/embor.2009.276
          2828749
          20075988
          34b0868a-200d-4509-944e-d42acb0e1a2f
          History

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