Detection of Pulmonary Embolism in Returning Travelers with Hypoxemic Pneumonia due to COVID-19 in Reunion Island

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Abstract.

The aim of this study was to evaluate the occurrence of pulmonary embolism in returning travelers with hypoxemic pneumonia due to COVID-19. All returning travelers to Reunion Island with hypoxemic pneumonia due to COVID-19 underwent computed tomography pulmonary angiography (CTPA) and were included in the cohort. Thirty-five patients were returning travelers with hypoxemic pneumonia due to COVID-19 and had recently returned from one of the countries most affected by the COVID-19 outbreak (mainly from France and Comoros archipelago). Five patients (14.3%) were found to have pulmonary embolism and two (5.9%) were incidentally found to have deep vein thrombosis on CTPA. Patients with pulmonary embolism or deep vein thrombosis had higher D-dimer levels than those without pulmonary embolism or deep vein thrombosis ( P = 0.04). Returning travelers with hypoxemic pneumonia due to COVID-19 should be systematically screened for pulmonary embolism.

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Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia

Songping Cui, Shuo Chen, Xiunan Li … (2020)

Abstract Background Three months ago, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) broke out in Wuhan, China, and spread rapidly around the world. Severe novel coronavirus pneumonia (NCP) patients have abnormal blood coagulation function, but their venous thromboembolism (VTE) prevalence is still rarely mentioned. Objectives To determine the incidence of VTE in patients with severe NCP. Methods In this study, 81 severe NCP patients in the intensive care unit (ICU) of Union Hospital (Wuhan, China) were enrolled. The results of conventional coagulation parameters and lower limb vein ultrasonography of these patients were retrospectively collected and analyzed. Results The incidence of VTE in these patients was 25% (20/81), of which 8 patients with VTE events died. The VTE group was different from the non‐VTE group in age, lymphocyte counts, activated partial thromboplastin time (APTT), D‐dimer, etc. If 1.5 µg/mL was used as the D‐dimer cut‐off value to predicting VTE, the sensitivity was 85.0%, the specificity was 88.5%, and the negative predictive value (NPV) was 94.7%. Conclusions The incidence of VTE in patients with severe NCP is 25% (20/81), which may be related to poor prognosis. The significant increase of D‐dimer in severe NCP patients is a good index for identifying high‐risk groups of VTE.

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First cases of coronavirus disease 2019 (COVID-19) in France: surveillance, investigations and control measures, January 2020

Sibylle Bernard Stoecklin, Patrick Rolland, Yassoungo Silue … (2020)

A novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) causing a cluster of respiratory infections (coronavirus disease 2019, COVID-19) in Wuhan, China, was identified on 7 January 2020. The epidemic quickly disseminated from Wuhan and as at 12 February 2020, 45,179 cases have been confirmed in 25 countries, including 1,116 deaths. Strengthened surveillance was implemented in France on 10 January 2020 in order to identify imported cases early and prevent secondary transmission. Three categories of risk exposure and follow-up procedure were defined for contacts. Three cases of COVID-19 were confirmed on 24 January, the first cases in Europe. Contact tracing was immediately initiated. Five contacts were evaluated as at low risk of exposure and 18 at moderate/high risk. As at 12 February 2020, two cases have been discharged and the third one remains symptomatic with a persistent cough, and no secondary transmission has been identified. Effective collaboration between all parties involved in the surveillance and response to emerging threats is required to detect imported cases early and to implement adequate control measures.

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Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2

Shiyu Yin, Ming Huang, Dengju Li … (2020)

Severe coronavirus disease 2019 (COVID-19) is commonly complicated with coagulopathy, the difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2 has not been analyzed. Coagulation results and clinical features of consecutive patients with severe pneumonia induced by SARS-CoV2 (COVID group) and non-SARS-CoV2 (non-COVID group) in Tongji hospital were retrospectively analyzed and compared. Whether patients with elevated D-dimer could benefit from anticoagulant treatment was evaluated. There were 449 COVID patients and 104 non-COVID patients enrolled into the study. The 28-day mortality in COVID group was approximately twofold of mortality in non-COVID group (29.8% vs. 15.4%, P = 0.003), COVID group were older (65.1 ± 12.0 vs. 58.4 ± 18.0, years, P 3.0 μg/mL (32.8% vs. 52.4%, P = 0.017). Patients with severe pneumonia induced by SARS-CoV2 had higher platelet count than those induced by non-SARS-CoV2, and only the former with markedly elevated D-dimer may benefit from anticoagulant treatment.

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Author and article information

Journal

Journal ID (nlm-ta): Am J Trop Med Hyg

Journal ID (iso-abbrev): Am. J. Trop. Med. Hyg

Journal ID (publisher-id): tpmd

Journal ID (hwp): tropmed

Title: The American Journal of Tropical Medicine and Hygiene

Publisher: The American Society of Tropical Medicine and Hygiene

ISSN (Print): 0002-9637

ISSN (Electronic): 1476-1645

Publication date (Print): August 2020

Publication date (Electronic): 1 July 2020

Publication date PMC-release: 1 July 2020

Volume: 103

Issue: 2

Pages: 844-846

Affiliations

[1 ]Pneumologie, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, Saint Denis, France;

[2 ]Radiologie, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, Saint Denis, France;

[3 ]Réanimation Polyvalente, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, Saint Denis, France;

[4 ]INSERM CIC 1410 Clinical and Epidemiology, University Hospital, Saint Denis, France;

[5 ]Department of Public Health and Research Support, Methodological Support and Biostatistics Unit, University Hospital, Saint Denis, France;

[6 ]Service des Maladies Infectieuses, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, Saint Denis, France

Author notes

[* ]Address correspondence to Nicolas Allou, Réanimation Polyvalente, Centre Hospitalier Universitaire Félix Guyon, Allée des Topazes, Saint-Denis 97405, France. E-mail: nicolas.allou@ 123456hotmail.fr

Disclosure: The present observational study was approved by the Ethics Committee of Infectious Disease and Tropical Medicine (CER-MIT) and was declared to the Commission nationale de l’informatique et des libertés (French Data Protection Agency or CNIL MR004, N° 2206739). The need for informed consent was waived, as the study was non-interventional and followed our usual protocol. The dataset used in the current study are available from the corresponding author on reasonable request.

Financial support: This work was internally funded.

Authors’ addresses: Kevin Larsen, Nathalie Coolen-Allou, Laurie Masse, Michel André, and Emilie Foch, Pneumologie, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, Saint Denis, France, E-mails: kevin.larsen0511@ 123456gmail.com , nathalie.allou@ 123456chu-reunion.fr , laurie.masse@ 123456chu-reunion.fr , michel.andre@ 123456chu-reunion.fr , and emilie.foch@ 123456chu-reunion.fr . Alexandre Angelino, Jérôme Allyn, Thierry Vitry, Jean Yves Travers, and Nicolas Allou, Réanimation Polyvalente, Centre Hospitalier Universitaire Felix Guyon, Saint Denis, France, E-mails: dinosangelino@ 123456gmail.com , jerome.allyn@ 123456chu-reunion.fr , thierry.vitry@ 123456chu-reunion.fr , jean-yves.travers@ 123456chu-reunion.fr , and nicolas.allou@ 123456hotmail.fr . Lea Bruneau and Adrien Maillot, Epidemiologie, Centre Hospitalier Universitaire Felix Guyon, Saint Denis, France, E-mails: lea.bruneau@ 123456chureunion.fr and adrien.maillot@ 123456chureunion.fr . Marie Lagrange-Xelot, Service des Maladies Infectieuses, Centre Hospitalier Universitaire Felix Guyon Allée des Topazes, Saint Denis, France, E-mail: marie.lagrange@ 123456chu-reunion.fr .

Article

Publisher ID: tpmd200597

DOI: 10.4269/ajtmh.20-0597

PMC ID: 7410458

PubMed ID: 32618261

SO-VID: 34c08360-ce77-4ade-bc27-4479284caa59

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Date received : 05 June 2020

Date accepted : 24 June 2020

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Detection of Pulmonary Embolism in Returning Travelers with Hypoxemic Pneumonia due to COVID-19 in Reunion Island

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Novel Coronavirus Disease COVID-19

Most cited references 8

Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia

First cases of coronavirus disease 2019 (COVID-19) in France: surveillance, investigations and control measures, January 2020

Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2

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