An observational study of matrix metalloproteinase (MMP)-9 in cystic fibrosis.

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Abstract

In cystic fibrosis (CF), cross-sectional studies have reported sputum matrix metalloproteinase (MMP)-9 to be elevated and negatively correlated with FEV1. This longitudinal study examined the association between MMP-9 and tissue inhibitors of metalloproteinases (TIMPs) to prognostic parameters in CF.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Cyst. Fibros.

Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

ISSN (Electronic): 1873-5010

ISSN (Print): 1569-1993

Publication date (Electronic): Sep 2014

Volume: 13

Issue: 5

Affiliations

[1 ] Section of Population Health, University of Aberdeen, Aberdeen AB25 2ZG, UK; Respiratory Medicine, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK. Electronic address: g.devereux@abdn.ac.uk.

[2 ] Respiratory Medicine, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK.

[3 ] Section of Population Health, University of Aberdeen, Aberdeen AB25 2ZG, UK.

[4 ] School of Nursing and Midwifery, University of Dundee, Dundee DD1 9SY, UK.

[5 ] TMRC Laboratory, University of Dundee, Dundee DD1 5EH, UK.

[6 ] Department of Paediatrics, Royal Aberdeen Children's Hospital, Aberdeen AB25 2ZG, UK.

[7 ] Department of Respiratory Medicine, Ninewells Hospital, Dundee DD1 9SY, UK.

[8 ] TMRC Laboratory, University of Dundee, Dundee DD1 5EH, UK; Discovery Translational Medicine, Pfizer Research, Collegeville, PA 19426, USA.

[9 ] Discovery Translational Medicine, Pfizer Research, Collegeville, PA 19426, USA.

Article

Publisher Item ID: S1569-1993(14)00033-2

DOI: 10.1016/j.jcf.2014.01.010

PubMed ID: 24525080

SO-VID: 34c84795-8910-4268-a7d2-28b8f4534b74

History

Keywords: Cystic fibrosis,FEV(1),MMP-9,Mortality,TIMP-1

Data availability:

Keywords: Cystic fibrosis, FEV(1), MMP-9, Mortality, TIMP-1

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