Coupled Plasma Filtration Adsorption

Abstract

Both pro-inflammatory and anti-inflammatory mediators participate in the pathogenesis of sepsis and explain the failure of specific therapies to improve survival. Continuous extracorporeal therapies have been proposed as a therapeutic option in sepsis. We have studied the effects of plasma filtration associated with adsorption in patients with septic shock. We have shown that such treatment may lead to improved survival in a rabbit model of sepsis and to improved hemodynamics, reduced norepinephrine dose and restoration of near-to-normal responsiveness of blood leukocytes to endotoxin in humans. It is anticipated that treatment of plasma, as a device modular to conventional hemofiltration, may pave the way to innovative approaches to the extracorporeal treatment of septic patients.

Journal

Journal ID (publisher-id): BPU

Journal ID (nlm-ta): Blood Purif

Journal ID (doi): 10.1159/issn.0253-5068

Title: Blood Purification

Publisher: S. Karger AG

ISBN: 978-3-8055-7371-9

ISBN: 978-3-318-00812-8

ISSN (Print): 0253-5068

ISSN (Electronic): 1421-9735

Publication date Subscription-year: 2002

Publication date (Print): 2002

Publication date (Electronic): 27 February 2002

Volume: 20

Issue: 3

Pages: 289-292

Affiliations

^aDepartment of Intensive Care and ^bDepartment of Nephrology, San Bortolo Hospital, Vicenza, and ^cClinical and Laboratory Research Department, Bellco, Mirandola, Italy

Article

Publisher ID: 47022 Other ID: Blood Purif 2002;20:289–292

DOI: 10.1159/000047022

PubMed ID: 11867877

Copyright statement: © 2002 S. Karger AG, Basel

License:

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Page count

Figures: 1, References: 20, Pages: 4

Product

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Categories

Subject: Proceedings of the 6th International Conference on CRRT