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      Suppression of progenitor differentiation requires the long noncoding RNA ANCR.

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          Abstract

          Long noncoding RNAs (lncRNAs) regulate diverse processes, yet a potential role for lncRNAs in maintaining the undifferentiated state in somatic tissue progenitor cells remains uncharacterized. We used transcriptome sequencing and tiling arrays to compare lncRNA expression in epidermal progenitor populations versus differentiating cells. We identified ANCR (anti-differentiation ncRNA) as an 855-base-pair lncRNA down-regulated during differentiation. Depleting ANCR in progenitor-containing populations, without any other stimuli, led to rapid differentiation gene induction. In epidermis, ANCR loss abolished the normal exclusion of differentiation from the progenitor-containing compartment. The ANCR lncRNA is thus required to enforce the undifferentiated cell state within epidermis.

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          Author and article information

          Journal
          Genes Dev
          Genes & development
          Cold Spring Harbor Laboratory
          1549-5477
          0890-9369
          Feb 15 2012
          : 26
          : 4
          Affiliations
          [1 ] Veterans Affairs Palo Alto Healthcare System, California 94304, USA.
          Article
          gad.182121.111
          10.1101/gad.182121.111
          3289881
          22302877
          3506f2c9-5f08-4ba3-bb17-80f3e1d878e1

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