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      Consensual improvement actions for the Tuberculosis Control Programme in Pernambuco state, Brazil: an e-Delphi study

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          Abstract

          Objectives: Tuberculosis (TB) remains a major public health problem, particularly in low and middle-income countries. The aim of this study is to consensualise improvement actions for the Tuberculosis Control Programme of the Pernambuco state (SPTC), Brazil. Methods: Firstly, a preliminary workshop was conducted with experts (n = 8), including key stakeholders and health professionals, to select structure and process indicators pertaining to the tuberculosis control programme. Then, an e-Delphi was carried out with a purposive sample of 11 local TB experts. The first-round questionnaire was comprised of 19 open-ended questions on possible improvement actions, based on programme indicators obtained in the previous stage. In the second-round experts rated each action for relevance and feasibility, using a four-point scale. In the last round the participants rated the actions again, in the light of group's answers. We used published criteria to define consensus at the outset of the study. Key findings: Eighty-nine improvement actions achieved a high degree of consensus in both feasibility and relevance in round three. Eighty-six actions were grouped under 19 structure and process indicators, while three were consideredcross-sectional in scope (i.e. related to more than one indicator). Ten out of the 86 actions obtained at least 70% of ratings on the highest score of the scale both for relevance and feasibility. These included: “Request and availability of sputum pots can be made by any health professional in the health unit”. Conclusions: The wide array of actions obtained in this Delphi represent a resource from which local SPTC services can select the actions most suitable for each context. The ten most relevant and feasible actions represent a particularly useful starting point to streamline change and potentially improve programme indicators.

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          Effectiveness of Electronic Reminders to Improve Medication Adherence in Tuberculosis Patients: A Cluster-Randomised Trial

          Background Mobile text messaging and medication monitors (medication monitor boxes) have the potential to improve adherence to tuberculosis (TB) treatment and reduce the need for directly observed treatment (DOT), but to our knowledge they have not been properly evaluated in TB patients. We assessed the effectiveness of text messaging and medication monitors to improve medication adherence in TB patients. Methods and Findings In a pragmatic cluster-randomised trial, 36 districts/counties (each with at least 300 active pulmonary TB patients registered in 2009) within the provinces of Heilongjiang, Jiangsu, Hunan, and Chongqing, China, were randomised using stratification and restriction to one of four case-management approaches in which patients received reminders via text messages, a medication monitor, combined, or neither (control). Patients in the intervention arms received reminders to take their drugs and reminders for monthly follow-up visits, and the managing doctor was recommended to switch patients with adherence problems to more intensive management or DOT. In all arms, patients took medications out of a medication monitor box, which recorded when the box was opened, but the box gave reminders only in the medication monitor and combined arms. Patients were followed up for 6 mo. The primary endpoint was the percentage of patient-months on TB treatment where at least 20% of doses were missed as measured by pill count and failure to open the medication monitor box. Secondary endpoints included additional adherence and standard treatment outcome measures. Interventions were not masked to study staff and patients. From 1 June 2011 to 7 March 2012, 4,292 new pulmonary TB patients were enrolled across the 36 clusters. A total of 119 patients (by arm: 33 control, 33 text messaging, 23 medication monitor, 30 combined) withdrew from the study in the first month because they were reassessed as not having TB by their managing doctor (61 patients) or were switched to a different treatment model because of hospitalisation or travel (58 patients), leaving 4,173 TB patients (by arm: 1,104 control, 1,008 text messaging, 997 medication monitor, 1,064 combined). The cluster geometric mean of the percentage of patient-months on TB treatment where at least 20% of doses were missed was 29.9% in the control arm; in comparison, this percentage was 27.3% in the text messaging arm (adjusted mean ratio [aMR] 0.94, 95% CI 0.71, 1.24), 17.0% in the medication monitor arm (aMR 0.58, 95% CI 0.42, 0.79), and 13.9% in the combined arm (aMR 0.49, 95% CI 0.27, 0.88). Patient loss to follow-up was lower in the text messaging arm than the control arm (aMR 0.42, 95% CI 0.18–0.98). Equipment malfunction or operation error was reported in all study arms. Analyses separating patients with and without medication monitor problems did not change the results. Initiation of intensive management was underutilised. Conclusions This study is the first to our knowledge to utilise a randomised trial design to demonstrate the effectiveness of a medication monitor to improve medication adherence in TB patients. Reminders from medication monitors improved medication adherence in TB patients, but text messaging reminders did not. In a setting such as China where universal use of DOT is not feasible, innovative approaches to support patients in adhering to TB treatment, such as this, are needed. Trial Registration Current Controlled Trials, ISRCTN46846388
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            Construção de indicadores qualitativos para avaliação de mudanças

            Apresenta-se uma reflexão teórico-metodológica focada na construção de indicadores qualitativos, voltados principalmente para a avaliação de mudanças no campo educacional. Foi escrito para subsidiar o processo de autoavaliação de um conjunto de escolas médicas que desenvolvem um programa de transformação de seus métodos tradicionais para outros fundamentados na filosofia e na prática de aprendizagem ativa. Nele são discutidos e problematizados: o conceito de indicador; a produção de indicadores para pesquisa avaliativa e a construção de indicadores qualitativos. Esses últimos são tratados sob duas formas mais frequentes: dentro da lógica quantitativa e da lógica qualitativa. Indicadores qualitativos a partir da visão quantitativa da realidade são construídos principalmente por meio de escalas. Dentro da ótica qualitativa, são elaborados a partir das representações e práticas dos sujeitos envolvidos na investigação. Enfatizando a necessidade de produção de indicadores de mudança que levem em conta estruturas, processos, relações e a contribuição da subjetividade, conclui-se que a validade interna desses indicadores pode ser alcançada quando as categorias empregadas em sua construção são fundamentadas teórica e contextualmente e possuem significados mútuos e partilhados entre os participantes.
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              Paying research participants: a study of current practices in Australia.

              To examine current research payment practices and to inform development of clearer guidelines for researchers and ethics committees.
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                Author and article information

                Journal
                AIMS Public Health
                AIMS Public Health
                PublicHealth
                AIMS Public Health
                AIMS Press
                2327-8994
                12 July 2019
                2019
                : 6
                : 3
                : 229-241
                Affiliations
                [1 ]Center of Biological Sciences, Post-graduation Programme in Therapeutic Innovation, Federal University of Pernambuco, Cidade Universitária, Recife, Pernambuco, Brazil
                [2 ]Unidade de Investigação e Desenvolvimento em Enfermagem (ui&de), Escola Superior de Enfermagem de Lisboa, Parque das Nações, Av. D. João II, 1990-096, Lisbon, Portugal
                [3 ]Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz,Quinta da Granja, 2829, 511 Monte de Caparica, Almada, Portugal
                [4 ]Department of Pharmacy Health Sciences Center, Federal University of Pernambuco-Av. MoraesRego, 123, Cidade Universitária, Recife, Pernambuco, Brazil
                Author notes
                * Correspondence: E-mail: simonesbezerra@ 123456gmail.com ; Tel: +558131841474.
                Article
                publichealth-06-03-229
                10.3934/publichealth.2019.3.229
                6779604
                350999c5-19d1-4704-b312-2f5395466b24
                © 2019 the Author(s), licensee AIMS Press

                This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0)

                History
                : 15 February 2019
                : 25 June 2019
                Categories
                Research Article

                tuberculosis,health programs and plans,quality improvement,delphi technique

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