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      Features and development of Coot

      a , * , b , c , d

      Acta Crystallographica Section D: Biological Crystallography

      International Union of Crystallography

      Experimental phasing and radiation damage

      Coot, model building

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          Abstract

          Coot is a molecular-graphics program designed to assist in the building of protein and other macromolecular models. The current state of development and available features are presented.

          Abstract

          Coot is a molecular-graphics application for model building and validation of biological macromolecules. The program displays electron-density maps and atomic models and allows model manipulations such as idealization, real-space refinement, manual rotation/translation, rigid-body fitting, ligand search, solvation, mutations, rotamers and Ramachandran idealization. Furthermore, tools are provided for model validation as well as interfaces to external programs for refinement, validation and graphics. The software is designed to be easy to learn for novice users, which is achieved by ensuring that tools for common tasks are ‘discoverable’ through familiar user-interface elements (menus and toolbars) or by intuitive behaviour (mouse controls). Recent developments have focused on providing tools for expert users, with customisable key bindings, extensions and an extensive scripting interface. The software is under rapid development, but has already achieved very widespread use within the crystallographic community. The current state of the software is presented, with a description of the facilities available and of some of the underlying methods employed.

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          Author and article information

          Conference
          Acta Crystallogr D Biol Crystallogr
          Acta Cryst. D
          Acta Crystallographica Section D: Biological Crystallography
          International Union of Crystallography
          0907-4449
          1399-0047
          01 April 2010
          24 March 2010
          24 March 2010
          : 66
          : Pt 4 ( publisher-idID: d100400 )
          : 486-501
          Affiliations
          [a ]Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England
          [b ]Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE-171 77 Stockholm, Sweden
          [c ]Department of Chemistry, University of California, 1156 High Street, Santa Cruz, CA 95064, USA
          [d ]Department of Chemistry, University of York, Heslington, York YO10 5DD, England
          Author notes
          Article
          ba5144 ABCRE6 S0907444910007493
          10.1107/S0907444910007493
          2852313
          20383002
          © Emsley et al. 2010

          This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.

          Experimental phasing and radiation damage
          Categories
          Research Papers

          Microscopy & Imaging

          model building, coot

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