Blog
About

  • Record: found
  • Abstract: found
  • Article: not found

Mechanisms of endocytosis.

1 ,

Annual review of biochemistry

Annual Reviews

Read this article at

ScienceOpenPublisherPubMed
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      Endocytic mechanisms control the lipid and protein composition of the plasma membrane, thereby regulating how cells interact with their environments. Here, we review what is known about mammalian endocytic mechanisms, with focus on the cellular proteins that control these events. We discuss the well-studied clathrin-mediated endocytic mechanisms and dissect endocytic pathways that proceed independently of clathrin. These clathrin-independent pathways include the CLIC/GEEC endocytic pathway, arf6-dependent endocytosis, flotillin-dependent endocytosis, macropinocytosis, circular doral ruffles, phagocytosis, and trans-endocytosis. We also critically review the role of caveolae and caveolin1 in endocytosis. We highlight the roles of lipids, membrane curvature-modulating proteins, small G proteins, actin, and dynamin in endocytic pathways. We discuss the functional relevance of distinct endocytic pathways and emphasize the importance of studying these pathways to understand human disease processes.

      Related collections

      Author and article information

      Affiliations
      [1 ] MRC Laboratory of Molecular Biology, Cambridge, United Kingdom. doherty@mrc-lmb.cam.ac.uk
      Journal
      Annu. Rev. Biochem.
      Annual review of biochemistry
      Annual Reviews
      1545-4509
      0066-4154
      2009
      : 78
      19317650 10.1146/annurev.biochem.78.081307.110540

      Comments

      Comment on this article