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Abstract
Innate immune responses provide the body with its first line of defense against infections.
Signals generated by a subset of lymphocytes, including natural killer (NK) cells
and natural killer T (NKT) cells, during the early host response might have an additional
role in determining the nature of downstream adaptive immune responses. Here, Fu-Dong
Shi, Hans-Gustaf Ljunggren and Nora Sarvetnick discuss the role of cellular and soluble
components of innate immunity in the development of autoimmune diseases. Some putative
pathways leading from innate immunity to autoimmunity are proposed.