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      Innate immunity and autoimmunity: from self-protection to self-destruction

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      Trends in Immunology
      Elsevier BV

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          Abstract

          Innate immune responses provide the body with its first line of defense against infections. Signals generated by a subset of lymphocytes, including natural killer (NK) cells and natural killer T (NKT) cells, during the early host response might have an additional role in determining the nature of downstream adaptive immune responses. Here, Fu-Dong Shi, Hans-Gustaf Ljunggren and Nora Sarvetnick discuss the role of cellular and soluble components of innate immunity in the development of autoimmune diseases. Some putative pathways leading from innate immunity to autoimmunity are proposed.

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          Author and article information

          Journal
          Trends in Immunology
          Trends in Immunology
          Elsevier BV
          14714906
          February 2001
          February 2001
          : 22
          : 2
          : 97-101
          Article
          10.1016/S1471-4906(00)01821-4
          11286711
          3533f435-2711-4f31-a9e3-aa6fdbbdb6f4
          © 2001

          https://www.elsevier.com/tdm/userlicense/1.0/

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