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      Histamine Agonist and Antagonist Drugs: Interference with CNS Control of GH Release in Rats

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          Abstract

          The effects of the administration into the brain ventricle of histamine, selective H<sub>1</sub> and H<sub>2</sub>-receptor agonists and antagonists and chemically similar substances with nonspecific activity on basal and morphine-stimulated growth homone (GH) secretion in normal male rats were studied. None of the drugs had any significant effect on baseline rat GH levels, but histamine and H<sub>1</sub> agonists were able to decrease the rat GH release evoked by morphine. Mepyramine (H<sub>1</sub> antagonist) had no consistent effect by itself but was effective in preventing the inhibitory action of 2-methylhistamine (H<sub>1</sub> agonist). H<sub>2</sub> agonists and antagonists and their chemical analogues were all inhibitory, but by a mechanism which is nonspecific and must be interpreted cautiously. These results confirm the inhibitory effect of histamine on rat GH release and indicate that H<sub>1</sub> receptors in the CNS are responsible for this effect.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1981
          1981
          25 November 2008
          : 14
          : 3
          : 180-191
          Affiliations
          Department of Pharmacology, School of Medicine, University of Milan, Italy
          Article
          179385 Horm Res 1981;14:180–191
          10.1159/000179385
          6116658
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 12
          Categories
          Original Paper

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