Neonatal Thymectomy Diminishes Renal IgA Deposition in IgA Nephropathy-Prone ddY Mice

Abstract

To understand the role of thymus-derived T cells in the development of IgA nephropathy (IgAN), we performed neonatal thymectomies on ddY mice, in which this disease occurs spontaneously. Although these thymectomized mice developed a renal lesion closely resembling that typical of IgAN, the extent of their mesangial IgA deposition was significantly milder than in control sham-operated mice. The immunological mechanisms responsible for curbing this mesangial deposition of IgA were then analyzed. The percentage of splenic T cells and the magnitude of mitogenic responses both decreased markedly in thymectomized compared with control mice. These results suggested the hypofunction of thymus-derived T cells. However, serum IgA levels were almost identical in both groups. Furthermore, sera from both groups contained similar amounts of macromolecular IgA, of the type formerly eluted from the affected glomeruli of patients with IgAN. These results strongly indicate that thymus-derived T cells or their products determine the amount of IgA deposited in the kidneys of ddY mice.

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1994

Publication date (Print): 1994

Publication date (Electronic): 16 December 2008

Volume: 66

Issue: 3

Pages: 326-332

Affiliations

^aDepartment of Internal Medicine, Saitama Medical Center, Saitama Medical School, Saitama, ^bDepartment of Internal Medicine, Jikei University School of Medicine, ^cDepartment of Medicine, Kidney Center, Tokyo Women’s Medical College, ^dDepartment of Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

Article

Publisher ID: 187831 Other ID: Nephron 1994;66:326–332

DOI: 10.1159/000187831

PubMed ID: 8190186

Copyright statement: © 1994 S. Karger AG, Basel

License:

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Page count

Pages: 7

Product

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Categories

Subject: Original Paper