Neonatal Thymectomy Diminishes Renal IgA Deposition in IgA Nephropathy-Prone ddY Mice

Abstract

To understand the role of thymus-derived T cells in the development of IgA nephropathy (IgAN), we performed neonatal thymectomies on ddY mice, in which this disease occurs spontaneously. Although these thymectomized mice developed a renal lesion closely resembling that typical of IgAN, the extent of their mesangial IgA deposition was significantly milder than in control sham-operated mice. The immunological mechanisms responsible for curbing this mesangial deposition of IgA were then analyzed. The percentage of splenic T cells and the magnitude of mitogenic responses both decreased markedly in thymectomized compared with control mice. These results suggested the hypofunction of thymus-derived T cells. However, serum IgA levels were almost identical in both groups. Furthermore, sera from both groups contained similar amounts of macromolecular IgA, of the type formerly eluted from the affected glomeruli of patients with IgAN. These results strongly indicate that thymus-derived T cells or their products determine the amount of IgA deposited in the kidneys of ddY mice.

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1994

Publication date (Print): 1994

Publication date (Electronic): 16 December 2008

Volume: 66

Issue: 3

Pages: 326-332

Affiliations

^aDepartment of Internal Medicine, Saitama Medical Center, Saitama Medical School, Saitama, ^bDepartment of Internal Medicine, Jikei University School of Medicine, ^cDepartment of Medicine, Kidney Center, Tokyo Women’s Medical College, ^dDepartment of Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

Article

Publisher ID: 187831 Other ID: Nephron 1994;66:326–332

DOI: 10.1159/000187831

PubMed ID: 8190186

SO-VID: 353e044d-2eaa-42c1-97cb-aa320a17c361

Copyright statement: © 1994 S. Karger AG, Basel

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Page count

Pages: 7

Product

Self URI (application/pdf): https://www.karger.com/Article/Pdf/187831

Self URI (text/html): https://www.karger.com/Article/FullText/187831

Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology

Categories

Subject: Original Paper