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      Neonatal Thymectomy Diminishes Renal IgA Deposition in IgA Nephropathy-Prone ddY Mice


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          To understand the role of thymus-derived T cells in the development of IgA nephropathy (IgAN), we performed neonatal thymectomies on ddY mice, in which this disease occurs spontaneously. Although these thymectomized mice developed a renal lesion closely resembling that typical of IgAN, the extent of their mesangial IgA deposition was significantly milder than in control sham-operated mice. The immunological mechanisms responsible for curbing this mesangial deposition of IgA were then analyzed. The percentage of splenic T cells and the magnitude of mitogenic responses both decreased markedly in thymectomized compared with control mice. These results suggested the hypofunction of thymus-derived T cells. However, serum IgA levels were almost identical in both groups. Furthermore, sera from both groups contained similar amounts of macromolecular IgA, of the type formerly eluted from the affected glomeruli of patients with IgAN. These results strongly indicate that thymus-derived T cells or their products determine the amount of IgA deposited in the kidneys of ddY mice.

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          Author and article information

          S. Karger AG
          16 December 2008
          : 66
          : 3
          : 326-332
          aDepartment of Internal Medicine, Saitama Medical Center, Saitama Medical School, Saitama, bDepartment of Internal Medicine, Jikei University School of Medicine, cDepartment of Medicine, Kidney Center, Tokyo Women’s Medical College, dDepartment of Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
          187831 Nephron 1994;66:326–332
          © 1994 S. Karger AG, Basel

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          Pages: 7
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