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      Perioperative Neurocognitive Disorder: State of the Preclinical Science

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          Summary

          The purpose of this white paper is to provide a succinct summary of the different experimental approaches that have been used in preclinical post-operative cognitive dysfunction research, and an overview of the knowledge that has accrued. This is not intended to be a comprehensive review, but rather is intended to highlight how the many different approaches have contributed to our understanding of post-operative cognitive dysfunction, and to identify knowledge gaps to be filled by further research. We have organized this report by the level of experimental and systems complexity, starting with molecular and cellular approaches, then moving to intact invertebrates and vertebrate animal models. In addition, our goal is to improve the quality and consistency of post-operative cognitive dysfunction /perioperative neurocognitive disorder research by promoting optimal study design, enhanced transparency, and “best practices” in experimental design and reporting to increase the likelihood of corroborating results. Thus, we conclude with general guidelines for designing, conducting and reporting perioperative neurocognitive disorder rodent research.

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          Author and article information

          Journal
          1300217
          533
          Anesthesiology
          Anesthesiology
          Anesthesiology
          0003-3022
          1528-1175
          26 July 2019
          January 2020
          01 January 2021
          : 132
          : 1
          : 55-68
          Affiliations
          [1. ]Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA USA
          [2. ]Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, CA, USA
          [3. ]Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard University Medical School, Boston, MA, USA.
          [4. ]Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
          [5. ]Department of Medicine, Oregon Health and Science University and VA Portland Health Care System, Portland, OR, USA
          [6. ]Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA USA
          [7. ]Department of Anesthesiology, Columbia University Irving Medical Center, New York, NY, USA
          [8. ]Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA
          [9. ]Department of Anesthesia, University of Toronto, Toronto, ON Canada
          Author notes
          Corresponding author: Roderic G Eckenhoff, MD, Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, 3620 Hamilton Walk, 311 John Morgan Bldg., Philadelphia, PA 19104, 215.746.8699, reckenho@ 123456pennmedicine.upenn.edu
          Article
          PMC6913778 PMC6913778 6913778 nihpa1535756
          10.1097/ALN.0000000000002956
          6913778
          31834869
          35507ba5-334f-4793-a033-57383a00d19b
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