Clinical Features and Outcome of Patients with Apical Hypertrophic Cardiomyopathy in Taiwan

Abstract

Objectives: The aim of this study was to analyze clinical characteristics and the outcome of patients with apical hypertrophic cardiomyopathy (ApHCM) followed in a Taiwan tertiary referral medical center. Background: ApHCM is regarded as a subgroup of nonobstructive HCM that occurs largely in Japanese patients. The clinical features, gender differences and prognosis of the disease in Taiwan are poorly understood. Methods: A retrospective cohort study with 40 patients was performed. Diagnosis was based on the demonstration of left ventricular hypertrophy by echocardiography. Clinical features, cardiovascular morbidity and mortality were analyzed. Multiple logistic regression was used to adjust for potential confounding factors. Results: Among 40 patients, males predominated with a percentage of 75%. The female patients obviously had later onset of presentation (mean age ± SD, 62.2 ± 5.7 vs. 54.1 ± 11.4 years; p = 0.038). During a mean follow-up of 72.2 ± 60.1 months, there was no mortality. However, 13 patients (32.5%) had one or more major cardiovascular morbidities, the most frequent being syncope or near syncope (15%) and ischemic stroke-associated atrial fibrillation (10%). In a multivariate analysis, left atrial enlargement (odds ratio 5.85, 95% CI 1.15–29.40; p = 0.034) was the only predictor of cardiovascular morbidity. Conclusions: Patients with ApHCM in Taiwan have a benign clinical course without association with sudden death and cardiovascular mortality. Left atrial enlargement was the only identified predictor of cardiovascular morbidity

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 2006

Publication date (Print): June 2006

Publication date (Electronic): 03 July 2006

Volume: 106

Issue: 1

Pages: 29-35

Affiliations

^aDepartment of Internal Medicine, ^bInstitute of Clinical Medicine, School of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ROC

Article

Publisher ID: 92590 Other ID: Cardiology 2006;106:29–35

DOI: 10.1159/000092590

PubMed ID: 16612066

Copyright statement: © 2006 S. Karger AG, Basel

License:

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Page count

Tables: 4, References: 22, Pages: 7

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Categories

Subject: Original Research