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      Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent.

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          Abstract

          Ultrasound molecular imaging is an emerging technique for sensitive detection of intravascular targets. Molecular imaging of angiogenesis has strong potential for both clinical use and as a research tool in tumor biology and the development of antiangiogenic therapies. Our objectives are to develop a robust ultrasound contrast agent platform using microbubbles (MB) to which targeting ligands can be conjugated by biocompatible, covalent conjugation chemistry, and to develop a pure low mechanical index (MI) imaging processing method and corresponding quantification method. The MB and the imaging methods were evaluated in a mouse model of breast cancer in vivo.

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          Author and article information

          Journal
          Invest Radiol
          Investigative radiology
          Ovid Technologies (Wolters Kluwer Health)
          1536-0210
          0020-9996
          Apr 2011
          : 46
          : 4
          Affiliations
          [1 ] Targeson, Inc, San Diego, CA, USA.
          Article
          NIHMS251801
          10.1097/RLI.0b013e3182034fed
          3075480
          21343825
          35667bff-0908-48a5-903d-976c3d79a3c4
          History

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