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      Tumor suppressors and cell metabolism: a recipe for cancer growth.

      1 ,
      Genes & development
      Cold Spring Harbor Laboratory

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          Abstract

          Growing tumors face two major metabolic challenges-how to meet the bioenergetic and biosynthetic demands of increased cell proliferation, and how to survive environmental fluctuations in external nutrient and oxygen availability when tumor growth outpaces the delivery capabilities of the existing vasculature. Cancer cells display dramatically altered metabolic circuitry that appears to directly result from the oncogenic mutations selected during the tumorigenic process. An emerging theme in cancer biology is that many of the genes that can initiate tumorigenesis are intricately linked to metabolic regulation. In turn, it appears that a number of well-established tumor suppressors play critical roles in suppressing growth and/or proliferation when intracellular supplies of essential metabolites become reduced. In this review, we consider the potential role of tumor suppressors as metabolic regulators.

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          Author and article information

          Journal
          Genes Dev
          Genes & development
          Cold Spring Harbor Laboratory
          1549-5477
          0890-9369
          Mar 01 2009
          : 23
          : 5
          Affiliations
          [1 ] Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, Quebec, H3A 1A3, Canada. russell.jones@mcgill.ca
          Article
          23/5/537
          10.1101/gad.1756509
          2763495
          19270154
          3569e9b6-49ea-40c7-b9c1-361586b245c6
          History

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