Not all measures of hyperinflation are created equal: lung structure and clinical correlates of gas trapping and hyperexpansion in COPD: the Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study.

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Abstract

Hyperinflation refers to a nonspecific increase in absolute lung volumes and has a poor prognosis in COPD. The relative contribution of increased airways resistance and increased parenchymal compliance to hyperinflation of each absolute lung volume is poorly understood. We hypothesized that increased residual volume (RV) and RV/total lung capacity (TLC) would be associated with reduced airway lumen dimensions, whereas increased functional residual capacity (FRC), TLC, and reduced inspiratory capacity (IC)/TLC would be associated with emphysema on CT scan. We examined whether clinical characteristics differed accordingly.

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Journal

Journal ID (iso-abbrev): Chest

Title: Chest

Publisher: American College of Chest Physicians

ISSN (Electronic): 1931-3543

ISSN (Print): 0012-3692

Publication date (Electronic): Jun 2014

Volume: 145

Issue: 6

Affiliations

[1 ] Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY; Department of Medicine, McGill University Health Center, Montreal, QC, Canada.

[2 ] Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA.

[3 ] Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY.

[4 ] Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

[5 ] Asthma and COPD Program, Division of Pulmonary and Critical Care, Feinberg School of Medicine, Northwestern University, Chicago, IL.

[6 ] Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY. Electronic address: rgb9@columbia.edu.

Article

Publisher Item ID: S0012-3692(15)34803-0

DOI: 10.1378/chest.13-1884

PMC ID: 4042513

PubMed ID: 24481056

SO-VID: 356a39dc-c716-4794-89ef-f7963396af05

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