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      Organic base-catalyzed stereodivergent synthesis of (R)- and (S)-3-amino-4,4,4-trifluorobutanoic acids

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          Fluorine in medicinal chemistry.

          It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.
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            Asymmetric construction of stereogenic carbon centers featuring a trifluoromethyl group from prochiral trifluoromethylated substrates.

             Jing Nie,  Hong Guo,  Jun Ma (2011)
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              Synthesis and applications of tert-butanesulfinamide.

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                Author and article information

                Journal
                CHCOFS
                Chemical Communications
                Chem. Commun.
                Royal Society of Chemistry (RSC)
                1359-7345
                1364-548X
                2012
                2012
                : 48
                : 34
                : 4124
                Article
                10.1039/c2cc30627a
                © 2012
                Product
                Self URI (article page): http://xlink.rsc.org/?DOI=c2cc30627a

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