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      Deconstruction of GCN4/GCRE into a monomeric peptide-DNA complex

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      Nature Structural & Molecular Biology

      Springer Nature

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          Most cited references 28

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          Hydrogen Bonding in Biological Structures

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            Coupling of local folding to site-specific binding of proteins to DNA.

             M. Record,  R S Spolar (1994)
            Thermodynamic studies have demonstrated the central importance of a large negative heat capacity change (delta C degree assoc) in site-specific protein-DNA recognition. Dissection of the large negative delta C degree assoc and the entropy change of protein-ligand and protein-DNA complexation provide a thermodynamic signature identifying processes in which local folding is coupled to binding. Estimates of the number of residues that fold on binding obtained from this analysis agree with structural data. Structural comparisons indicate that these local folding transitions create key parts of the protein-DNA interface. The energetic implications of this "induced fit" model for DNA site recognition are considered.
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              The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins

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                Author and article information

                Journal
                Nature Structural & Molecular Biology
                Nat Struct Mol Biol
                Springer Nature
                1545-9993
                1545-9985
                June 1995
                June 1 1995
                June 1995
                : 2
                : 6
                : 450-457
                Article
                10.1038/nsb0695-450
                © 1995

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