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      Shotgun proteomic analysis of tiger milk mushroom (Lignosus rhinocerotis) and the isolation of a cytotoxic fungal serine protease from its sclerotium.

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          Abstract

          The sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden (tiger milk mushroom) has been traditionally used as a complementary and alternative medicine for cancer treatment by the local communities of Southeast Asia. Despite the continuous research interest in its antiproliferative activity, the identity of the bioactive compound(s) responsible has yet to be determined. This study aims to bridge the gap in existing research literature by using proteomics approach for investigation of the nature of the anticancer substance of L. rhinocerotis.

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          Author and article information

          Journal
          J Ethnopharmacol
          Journal of ethnopharmacology
          1872-7573
          0378-8741
          Nov 4 2015
          : 174
          Affiliations
          [1 ] Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: yean_ny_nie@yahoo.com.
          [2 ] Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
          [3 ] Ligno Biotech Sdn Bhd, 43300 Balakong Jaya, Selangor, Malaysia.
          Article
          S0378-8741(15)30109-4
          10.1016/j.jep.2015.08.042
          26320692
          35879f2c-7bcb-4f4c-92c3-cd50af3c3797
          Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
          History

          Cytotoxicity,Lignosus rhinocerotis,Proteome,Serine protease,nano-ESI-LC-MS/MS

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