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      Alternative procedure for charged derivatization to enhance detection responses of steroids in electrospray ionization-MS.

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          Abstract

          A derivatization procedure has been examined to enhance the electrospray ionization (ESI)-MS detectabilities of steroids that charged derivatization is not suitable for. The derivatization procedure with 2-hydrazinopyridine or isonicotinoyl azide was very effective for the sensitive detection of di-oxosteroids or di-hydroxysteroids, respectively, and the detection limits of the resulting derivatives were as low as about 2 fmol. The derivatives also provided intense characteristic product ions in the MS-MS, which are expected to be usable for the selected reaction monitoring mode.

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          Author and article information

          Journal
          Chem Pharm Bull (Tokyo)
          Chemical & pharmaceutical bulletin
          Pharmaceutical Society of Japan
          0009-2363
          0009-2363
          Apr 2007
          : 55
          : 4
          Affiliations
          [1 ] Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Japan. higashi@p.kanazawa-u.ac.jp
          Article
          JST.JSTAGE/cpb/55.662
          10.1248/cpb.55.662
          17409568
          35891d4d-01b6-4817-b789-5610ecb50841
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