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      Robust relationship inference in genome-wide association studies.

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          Abstract

          Genome-wide association studies (GWASs) have been widely used to map loci contributing to variation in complex traits and risk of diseases in humans. Accurate specification of familial relationships is crucial for family-based GWAS, as well as in population-based GWAS with unknown (or unrecognized) family structure. The family structure in a GWAS should be routinely investigated using the SNP data prior to the analysis of population structure or phenotype. Existing algorithms for relationship inference have a major weakness of estimating allele frequencies at each SNP from the entire sample, under a strong assumption of homogeneous population structure. This assumption is often untenable.

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          Author and article information

          Journal
          Bioinformatics
          Bioinformatics (Oxford, England)
          Oxford University Press (OUP)
          1367-4811
          1367-4803
          Nov 15 2010
          : 26
          : 22
          Affiliations
          [1 ] Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
          Article
          btq559
          10.1093/bioinformatics/btq559
          3025716
          20926424
          3593b4e3-0496-4c2f-b923-bfde3d9954a2
          History

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