The present study reports on the relations between multicultural personality and ethnic tolerance via associations with cross-group friendship in a sample of Portuguese university students (n = 270). It was found that the multicultural personality dimensions, particularly cultural empathy, open-mindedness, social initiative, and flexibility, were significantly correlated with ethnic tolerance. At the same time, a mediation model demonstrated that the relationship between open-mindedness and ethnic tolerance was partially mediated by cross-group friendship. In addition, emotional stability was found to be indirectly related to ethnic tolerance via its association with cross-group friendship. These findings highlight the importance of considering individual and contact variables in promoting tolerance toward representatives of diverse ethnic and cultural groups.