Bahare Salehi 1 , 2 , Nanjangud V. Anil Kumar 3 , Bilge Şener 4 , Mehdi Sharifi-Rad 5 , * , Mehtap Kılıç 4 , Gail B. Mahady 6 , Sanja Vlaisavljevic 7 , Marcello Iriti 8 , * , Farzad Kobarfard 9 , 10 , William N. Setzer 11 , * , Seyed Abdulmajid Ayatollahi 9 , 12 , 13 , Athar Ata 13 , Javad Sharifi-Rad 9 , 13 , *
14 May 2018
Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies. Plant-derived natural products continue to serve as a reservoir for the discovery of new medicines, including anti-HIV agents. This review presents a survey of plants that have shown anti-HIV activity, both in vitro and in vivo.