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      Impact of Cardiovascular Risk Factors on Morbidity and Mortality in Czech Middle-Aged Men: Pilsen Longitudinal Study

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          The impact of biological and life-style characteristics measured during baseline examination on 12-year morbidity and mortality of coronary heart disease (CHD), stroke (STR), and malignancies was investigated in an urban population of 3,540 middle-aged men initially free of clinical disease. The following factors enhanced significantly (at the 5 % level) the adjusted relative risk ratios: for total mortality age, smoking, and elevated systolic blood pressure; for CHD age, smoking, elevated systolic blood pressure, serum cholesterol levels, and body mass index, and family history (father or mother). Myocardial infarction was positively associated with age, smoking and elevated serum cholesterol levels. For STR age and elevation of both systolic and diastolic blood pressure were risk factors. The relative risk for all malignancies was enhanced by age and smoking. Regular alcohol consumption was associated with a significantly lower risk for all CHD; however, with only marginal significance for myocardial infarction. Higher education was associated with a significantly lower risk of total mortality, all CHD, and myocardial infarction and a marginally lower risk of STR. A high leisure physical activity was negatively (but not significantly) associated with the risk of all end points.

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          Author and article information

          S. Karger AG
          18 November 2008
          : 85
          : 1
          : 61-68
          2nd Department of Internal Medicine, Center of Preventive Medicine, Medical Faculty of the Charles University, Pilsen, Czech Republic
          176647 Cardiology 1994;85:61–68
          © 1994 S. Karger AG, Basel

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          Page count
          Pages: 8
          Epidemiology and Prevention


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