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      Targeted gene therapy to antigen-presenting cells in the central nervous system using hematopoietic stem cells.

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      Neurological research

      Maney Publishing

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          Abstract

          Hematopoietic stem cells (HSC) have been previously used as vectors for gene therapy of systemic disease. The effectiveness of HSC-mediated gene therapy largely depends on efficient gene delivery into long-term repopulating progenitors and targeted transgene expression in an appropriate progeny of the transduced pluripotent HSCs. In the present study, we examined the feasibility of using HSC transduced with self-inactivating (SIN) lentiviral vectors for the delivery of gene therapy to the central nervous system (CNS).

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          Author and article information

          Journal
          Neurol. Res.
          Neurological research
          Maney Publishing
          0161-6412
          0161-6412
          Dec 2005
          : 27
          : 8
          Affiliations
          [1 ] Section of Neurosurgery, The University of Chicago Pritzker School of Medicine, USA. mlesniak@syrgery.bsd.uchicago.edu
          10.1179/016164105X49454
          16354542

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