To quantify left ventricular (LV) function and mass (LVM) derived from dual-source
computed tomography (DSCT) and the influence of beta-blocker administration compared
to cardiac magnetic resonance imaging (CMR).
Thirty-two patients undergoing cardiac DSCT and CMR were included, where of fifteen
received metoprolol intravenously before DSCT. LV parameters were calculated by the
disc-summation method (DSM) and by a segmented region-growing algorithm (RGA). All
data sets were analyzed by two blinded observers. Interobserver agreement was tested
by the intraclass correlation coefficient. RESULTS.: 1. Using DSM LV parameters were
not statistically different between DSCT and CMR in all patients (DSCT vs. CMR: EF
63+/-8% vs. 64+/-8%, p=0.47; EDV 136+/-36 ml vs. 138+/-35 ml, p=0.66; ESV 52+/-21
ml vs. 52+/-22 ml, p=0.61; SV 83+/-22 ml vs. 87+/-19 ml, p=0.22; CO 5.4+/-0.9l/min
vs. 5.7+/-1.2l/min, p=0.09, LVM 132+/-33 g vs. 132+/-33 g, p=0.99). 2. In a subgroup
of 15 patients beta-blockade prior to DSCT resulted in a lower ejection fraction (EF),
stroke volume (SV), cardiac output (CO) and increase in end systolic volume (ESV)
in DSCT (EF 59+/-8% vs. 62+/-9%; SV 73+/-17 ml vs. 81+/-15 ml; CO 5.7+/-1.2l/min vs.
5.0+/-0.8 l/min; ESV 52+/-27 ml vs. 57+/-24 ml, all p<0.05). 3. Analyzing the RGA
parameters LV volumes were not significantly different compared to DSM, whereas LVM
was higher using RGA (177+/-31 g vs. 132+/-33 g, p<0.05). Interobserver agreement
was excellent comparing DSM values with best agreement between RGA calculations.
Left ventricular volumes and mass can reliably be assessed by DSCT compared to CMR.
However, beta-blocker administration leads to statistically significant reduced EF,
SV and CO, whereas ESV significantly increases. DSCT RGA reliably analyzes LV function,
whereas LVM is overestimated compared to DSM.
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.