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Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae
Jing Yuan ,
Chen Chen ,
Jinghua Cui ,
Jing Lu ,
Chao Yan ,
Xiao Wei ,
Xiangna Zhao ,
NanNan Li ,
Shaoli Li ,
Guanhua Xue ,
Weiwei Cheng ,
Boxing Li ,
Huan Li ,
Weishi Lin ,
Changyu Tian ,
Jiangtao Zhao ,
Juqiang Han ,
Daizhi An ,
Qiong Zhang ,
Hong Wei ,
Minghua Zheng ,
Xuejun Ma ,
Wei Li ,
Xiao Chen ,
Zheng Zhang ,
Hui Zeng ,
Sun Ying ,
JianXin Wu ,
Ruifu Yang ,
Di Liu
September 2019
September 2019
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Abstract
The underlying etiology of nonalcoholic fatty liver disease (NAFLD) is believed to
be quite varied. Changes in the gut microbiota have been investigated and are believed
to contribute to at least some cases of the disease, though a causal relationship
remains unclear. Here, we show that high-alcohol-producing Klebsiella pneumoniae (HiAlc
Kpn) is associated with up to 60% of individuals with NAFLD in a Chinese cohort. Transfer
of clinical isolates of HiAlc Kpn by oral gavage into mice induced NAFLD. Likewise,
fecal microbiota transplant (FMT) into mice using a HiAlc-Kpn-strain-containing microbiota
isolated from an individual with NASH induced NAFLD. However, selective elimination
of the HiAlc Kpn strain before FMT prevented NAFLD in the recipient mice. These results
suggest that at least in some cases of NAFLD an alteration in the gut microbiome drives
the condition due to excess endogenous alcohol production.