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      Relations Between Residential Proximity to EPA-Designated Toxic Release Sites and Diffuse Large B-Cell Lymphoma Incidence

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          Abstract

          Objectives

          Examining the spatial patterns of diffuse large B-cell lymphoma (DLBCL) incidence and residential proximity to toxic release locations may provide insight regarding environmental and sociodemographic risk factors.

          Methods

          We linked and geocoded cancer incidence data for the period 1999–2008 from the Georgia Comprehensive Cancer Registry with population data from the US Census and the Environmental Protection Agency's Toxics Release Inventory. We conducted cluster analyses and constructed Poisson regression models to assess DLBCL incidence as a function of mean distance to the toxic release sites.

          Results

          In total, 3851 incident DLBCL cases occurred among adults residing in Georgia between 1999 and 2008. Significant focal clustering was observed around 57% of ethylene oxide sites, 5% of benzene sites, 9% of tetrachloroethylene sites, 7% of styrene sites, 10% of formaldehyde sites, 5% of trichloroethylene sites, and 10% of all release sites. Mean distance to sites was significantly associated with DLBCL risk for all chemicals.

          Conclusions

          Proximity to Toxics Release Inventory sites can be linked to increased DLBCL risk as assessed through focal clustering and Poisson regression, and confirmatory studies using geospatial mapping can aid in further specifying risk factors for DLBCL.

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          Author and article information

          Journal
          0404522
          7555
          South Med J
          South. Med. J.
          Southern medical journal
          0038-4348
          1541-8243
          6 October 2016
          October 2016
          01 October 2017
          : 109
          : 10
          : 606-614
          Affiliations
          Division of Epidemiology and Biostatistics, University of Illinois at Chicago School of Public Health, Chicago, the University of Texas MD Anderson Cancer Center, Houston, the Departments of Hematology and Oncology and Biostatistics and Bioinformatics Shared Resource, Winship Cancer Institute, and the Departments of Epidemiology and Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, Georgia, and the Georgia Department of Public Health, Atlanta.
          Author notes
          Correspondence to Dr Christopher Flowers, Department of Hematology and Oncology/Winship Cancer Institute, Emory University, 1365 Clifton Rd, NE, Building B, Suite 4302, Atlanta, GA 30322. crflowe@ 123456emory.edu .
          Article
          PMC5076563 PMC5076563 5076563 nihpa809311
          10.14423/SMJ.0000000000000545
          5076563
          27706495
          35d6179c-7b9c-4c37-89f2-8bd207d1d455

          To purchase a single copy of this article, visit sma.org/smj-home. To purchase larger reprint quantities, please contact reprints@ 123456wolterskluwer.com .

          History
          Categories
          Article

          epidemiology,lymphoma,non-Hodgkin lymphoma,diffuse large B-cell lymphoma

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