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      Paracrine Regulation of Bone Remodeling

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          Abstract

          Bone remodeling tightly couples resorption and formation in a cell unit called bone modeling unit (BMU). The activity of the BMU leads to a negative balance of bone mass in adults with physiological osteopenia. The regulation of the BMU is done at a local level by paracrine and autocrine factors such as cytokines and at an endocrine level by hormones. The hormonal level has been widely discussed in previous reviews and recent studies focus on the relations between hormonal triggers and cytokine-mediated responses to their stimulations. This review is dedicated to the means of coupling osteoblasts and osteoclasts and the recruitment of early cell precursors that originate in the hematopoietic bone marrow. Bone should be considered not only as an individual organ but as integrated in the bone-bone marrow organ.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-6124-2
          978-3-318-01661-1
          1663-2818
          1663-2826
          1995
          1995
          05 December 2008
          : 43
          : 1-3
          : 69-75
          Affiliations
          Department of Endocrinology, CHU de Nancy, Vandœuvre, France
          Article
          184240 Horm Res 1995;43:69–75
          10.1159/000184240
          7721265
          © 1995 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Endocrine Functions and Ageing

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